Progress of hyperhomocysteinemia hazard and pathogenesis
10.3969/j.issn.1001-1978.2014.09.006
- VernacularTitle:高同型半胱氨酸血症危害及致病机制研究进展
- Author:
Yanyan DONG
;
Guangliang CHEN
- Publication Type:Journal Article
- Keywords:
hyperhomocysteinemia;
cardiac-cerebralvascular diseases;
neurological diseases;
diabetic complications;
patho-genesis;
progress
- From:
Chinese Pharmacological Bulletin
2014;(9):1205-1208
- CountryChina
- Language:Chinese
-
Abstract:
Homocysteine ( Hcy) is an independent risk factor for a variety of diseases and closely related to cardiac-cerebralvascu-lar diseases, neurological diseases, diabetes and diabetic com-plications. High homocysteine levels can significantly increase the recurrence risks of cardiac-cerebralvascular events and stroke in patients with stroke, leading to high all-cause mortality. The risk of Alzheimer’s disease is increased by 1. 8 fold when the concentration of Hcy is over 14 μmol·L-1 . For each 5 μmol· L-1 increase in plasma Hcy in diabetes patients, the mortality rate increases by 5 fold in the next five years. High Hcy triggers the pathogenesis of diseases via multiple mechanisms including oxidative stress, lesions of vascular endothelial cells, prolifera-tion of vascular smooth muscle cells, dysfunction of coagulation and lipid metabolism and genomic hypomethylation etc.
