Effect of echinacoside on learning-memory ability and oxygen free radicals on model rats with Alzheimer's disease
10.3969/j.issn.1001-1978.2014.09.025
- VernacularTitle:松果菊苷对阿尔采末病模型大鼠学习、记忆功能及氧自由基水平的影响
- Author:
Hui DING
;
Hong CHEN
;
Yong JIANG
;
Pengfei TU
;
Jingyi MA
;
Wanxin ZHANG
- Publication Type:Journal Article
- Keywords:
echinacoside;
Alzheimer's disease;
Mor-ris water maze;
amyloid β-protein fragment 25 -35;
oxygen free radicals;
hippocampus;
cerebral cortex
- From:
Chinese Pharmacological Bulletin
2014;(9):1302-1305
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of echina-coside ( ECH ) on the learning and memory capacities and brain level of oxygen free radicals of rats with de-mentia induced by amyloid β-peptide. Methods Six-ty Sprague Dawley rats, weighing (300±10) g, were randomly divided with 10 rats pergroup into 6 groups:sham operated group, model, ECH high dose (40 mg ·kg-1·d-1), ECH middle dose (20 mg· kg-1· d-1), ECH low dose (10 mg·kg-1·d-1) and Hup A (Huperzine A, 0. 02 mg·kg-1·d-1) group. Mor-ris maze tests were conducted for evaluating the learn-ing and memory ability. Content of malondialdehyde (MDA), nitric oxide (NO) and activities of superox-ide dismutase ( SOD) and NO synthase ( NOS) in the hippocampus and cortex were detected. ResultsAβ25-35 induced significant learning and memory im-pairment in the rats. Compared with the rats in model group, those treated with ECH at different doses all manifested alleviation of learning and memory impair-ment ( P<0 . 01 , P<0 . 05 ) . Cotents of MDA of ECH treatment group were obviously decreased, while SOD activities were obviously increased, and significantly reduced the release of NO and NOS in the hippocam-pus and cortex brain tissue ( P <0 . 01 , P <0.05 ) . Conclusion ECH can enhance the learning and mem-ory ability in rats with AD, which is presumably relat-ed to accelerating the cleaning of oxygen free radicals and reducing oxidative stress in brain of AD rats.
