A case control study on risk factors for dose wearing off in Parkinson's disease patients
10.3969/j.issn.1009-0126.2014.09.004
- VernacularTitle:帕金森病剂末现象危险因素的病例对照研究
- Author:
Fangfei LI
;
Xin LI
;
Tao FENG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
levodopa;
risk factors;
drug dosage calculations
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2014;(9):906-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the risk factors for dose wearing off (WO)in PD patients .Methods One hundred and thirty-three PD patients were recruited in this study according to the UKPDBB criteria .Their dose WO was diagnosed according to the Wo questionnaire 9 (WOQ-9) .The pa-tients were divided into WOQ-9 (+ ) group (n=111) and WOQ-9 (-) group (n=22) .The pa-tients in WOQ-9 (+) group were further divided int WO (+ ) group (n=59) and WO (-) group (n=52) .The difference in their clinical and therapeutic parameters was compared .Results The dose WO was observed in 83 .5% of the 133 PD patients ,53 .2% of which accorded with the dose WO clinical definition .T he disease onset age ,disease course ,maximal levodopa daily dose and ac-cumulated levodopa dose differed greatly in WOQ-9 (+ ) group and WOQ-9 (-) group (P<005) . The disease course ,H-Y stage ,UPDRS score ,tetany score ,maximal levodopa daily dose ,levodopa dose per body weight and accumulated drug use time differed greatly in WOQ-9 (+ ) group and WOQ-9 (-) group (P< 0 .01) .The major risk of dose WO was the levodopa dose per body weight (OR=1.364 ,P<0 .05) .Conclusion Dose WO is related with the progress of disease and the use of levodopa .Levodopa dose per body weight is an independent risk factor for dose WO .
