Research progress of the antidepressants targeting the glutamate receptors
10.3969/j.issn.1001-1978.2014.09.004
- VernacularTitle:针对谷氨酸能系统的抗抑郁药物的研究进展
- Author:
Bing ZHANG
;
Yang LI
- Publication Type:Journal Article
- Keywords:
depression;
neuropsychiatric disorder;
monoamin-ergic system;
glutamatergic system;
antidepressants;
NMDA
- From:
Chinese Pharmacological Bulletin
2014;(9):1197-1200
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a worldwide neuropsychiatric disorder. Currently most preclinical and clinical studies of depression focus on monoaminergic system. However, there is growing evidence which suggests that glutamatergic system plays a critical role in the pathophysiology of depression. This review focuses on the de-velopment of new antidepressants that target glutamatergic sys-tem, summarizes the current mechanisms of antidepressants, and also highlights new insights to the pathophysiology of depression.
