Therapeutic effect of high-dose atorvastatin on acute ischemic stroke

VernacularTitle:大剂量阿托伐他汀治疗急性脑梗死患者的疗效观察
Author: Quanxin ZHANG
Publication Type:Journal Article
Keywords: brain infarction; platelet aggregation inhibitors; carotid artery diseases; atorvastatin
From: Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2014;(8):843-845
CountryChina
Language:Chinese
Abstract: Objective To study the therapeutic effect of high-dose atorastatin on acute ischemic stroke (AIS) .Methods One hundred and twenty-six AIS patients were randomly divided into treatment group and control group (63 in each group) .The therapeutic effect of high-dose atora-statin and nerve function scores were compared 2 weeks after the patients in control group re-ceived anti-platelet aggregation ,cerebral protection and radical scavenging treatment and those in treatment group underwent anti-platelet aggregation ,cerebral protection and radical scavenging treatment plus atorvastatin treatment (60 mg/d) .Results The effective and very effective rates were significantly higher and the NIHSS score of nerve function was significantly lower in treat-ment group than in control group (66 .67% vs 44 .44% ,P<0 .05 ,88 .89% vs 63 .49% ,P<0 .01 ;10 .1 ± 1 .5 vs 15 .5 ± 1 .2 ,P<0 .01) .No severe adverse reacrion occurred in two groups .Conclu-sion Hgh-dose atorastatin is very effective and safe for AIS with no significant adverse effect , and is thus worthy of popularization in clinical practice .