Approach to the patient with hypophosphatemic osteomalacia
10.3760/cma.j.issn.1000-6699.2014.08.015
- VernacularTitle:低磷性骨软化症的临诊应对
- Author:
Hongquan DU
;
Yan ZHENG
;
Zhenlin ZHANG
- Publication Type:Journal Article
- Keywords:
Hypophosphatemic osteomalacia;
Bone pain;
Pseudo-fractures
- From:
Chinese Journal of Endocrinology and Metabolism
2014;(8):697-700
- CountryChina
- Language:Chinese
-
Abstract:
A 47-year-old Chinese man with hypophosphatemic osteomalacia suffered from bone pain, difficulty in walking and pseudo-fractures. Biochemical examination showed a lowered serum phosphorus level and an elevated alkaline phosphatase level. The X-ray examination showed pseudo-fractures of multiple ribs, low bone density, biconcave deformities of the lumbar vertebrae, and pseudo-fracture of the right superior ramus of the pubis. A diagnosis of hypophosphatemic osteomalacia was made. The case was treated with oral neutral phosphate solution, calcitriol and Caltrate D. After treatment for two years, biochemical indicators were improved, and pseudo-fractures healed. Clinically, hypophosphatemic osteomalacia is often overlooked or misdiagnosed. In addition, the duration and dosage of these drugs should be appropriate, in order to avoid tertiary hyperparathyroidism or poor response to treatment.
