Research progress in building animal model of Graves'disease
10.3760/cma.j.issn.1000-6699.2014.08.020
- VernacularTitle:构建Graves病动物模型的研究进展
- Author:
Wei ZHENG
;
Jian TAN
- Publication Type:Journal Article
- Keywords:
Graves'disease;
Animal model;
Thyrotropin receptor
- From:
Chinese Journal of Endocrinology and Metabolism
2014;(8):716-719
- CountryChina
- Language:Chinese
-
Abstract:
The establishment animal model of Graves’ disease contributes to the study of etiology, pathogenesis and therapeutic modalities. After decades of studies and making improvements, the method of building mice model of Graves’disease has achieved a great development. Although there were many reports of animal model building in Graves’disease, as a mature technology A-subunit of thyrotropin receptor( TSHR)-expressing adenovirus was used to establish Graves’disease mice model, which has been accepted widely because of its high efficacy.
