The correlation analysis of primary hypothyroidism and serum small dense low density lipoprotein-cholesterol concentration
10.3969/j.issn.1673-4130.2014.17.005
- VernacularTitle:原发性甲状腺功能减退与血清小而密低密度脂蛋白胆固醇水平的相关分析
- Author:
Junfei YUAN
;
Jie LIN
;
Weiju KONG
;
Li XIAO
;
Liping CHEN
- Publication Type:Journal Article
- Keywords:
hypothroidism;
small dense low-density lipoprotein;
thyroid hormones;
atherosclerosis
- From:
International Journal of Laboratory Medicine
2014;(17):2282-2284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the serum small dense low density lipoprotein-cholesterol (sdLDL-C)concentration in patients with clinical and sub-clinical primary hypothyroidism,and to explore the clinical significance of serum sdLDL-C determination in pa-tients with hypothyroidism.Methods 60 patients with clinical hypothyroidism(clinical hypothyroidism group),96 cases with sub-clinical hypothyroidism(sub-clinical hypothyroidism group)and 132 normal subjects (normal group)were enrolled in the study. FT3,FT4,thyroid stimulating hormone (TSH),TG,TC,HDL-C,LDL-C,apolipoprotein AⅠ(ApoAⅠ),apolipoprotein B (ApoB), and sdLDL-C concentrations were measured.Analysis of Variance,Kruskal-Wallis H test and Spearman rank correlation analysis were used for statistical analysis.Results The concentration of sdLDL-C in sub-clinical hypothyroidism group was significantly higher than that in normal group (t=5.78,P <0.01),the concentration of sdLDL-C in clinical hypothyroidism group was signifi-cantly higher than that in sub-clinical hypothyroidism group(t=-2.88,P <0.01)and in normal group (t=6.68,P <0.01).There was statistically significant difference among groups (F =37.66,P <0.01).Correlation analysis showed that sdLDL-C in primary hypothyroidism patients was positively correlated with LgTSH (r =0.203,P =0.011 ),and negatively correlated with FT4 (r =-0.169,P =0.035).Conclusion The high concentration of sdLDL-C is a manifestation of dyslipidemia in primary hypothyroidism patients,and an important risk factor for atherosclerosis in primary hypothyroidism patients.
