Association between the GGN tri-nucleotide repeat polymorphism in androgen receptor gene and prostate cancer risk:a systematic review and meta-analysis
10.3969/j.issn.1673-4130.2014.17.010
- VernacularTitle:雄激素受体基因中 GGN 三核苷酸重复序列多态性与前列腺癌风险的相关性研究的系统综述与 meta 分析
- Author:
Aiqing YU
;
Xiaowen YANG
;
Pei HU
;
Shirong YAN
- Publication Type:Journal Article
- Keywords:
androgen receptor;
GGN polymorphism;
meta-analysis;
prostate cancer
- From:
International Journal of Laboratory Medicine
2014;(17):2293-2295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide a powerful and conclusive result for the association between the GGN polymorphic repeats in androgen receptor (AR)gene and prostate cancer (PCa)risk.Methods CNKI,VIP,Wanfang,PubMed/Medline,Embase and The Cochrance Library electronic database were used to retrieve the eligible publications addressing the association between the AR gene GGN polymorphic repeats and prostate cancer risk.16 GGN polymorphism repeats were used as cut off value,meta-analysis was ap-plied to the study on the association between the length of polymorphism repeats and prostate cancer risk.Results 9 cases of con-trol studies were included in this meta-analysis and a total of 2 438 cases and 1 968 controls were included.People with ≤16 GGN polymorphism repeats displayed a higher risk of prostate cancer(OR =1.15,95%CI :1.00 -1.31,P =0.04).Conclusion ≤16 GGN polymorphism repeats polymorphism associated with increased risk of prostate cancer.
