The relationship between serum cystatin C concentration and the severity of ACS patients with lesions degree and PCI treatment prognosis
10.3969/j.issn.1673-4130.2014.17.012
- VernacularTitle:胱抑素C水平与急性冠脉综合征患者病变程度及PCI治疗预后的关系
- Author:
Jiaming LI
;
Fuchun XIA
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
cystatin C;
prognosis
- From:
International Journal of Laboratory Medicine
2014;(17):2298-2300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum cystatin C concentration and severity of coronary artery disease and prognosis after peripheval component interconnet(PCI)treatment.Methods 352 patients diagnosed as ACS and received PCI treatment successfully were enrolled in the study as ACS group.In addition to that,60 people who underwent coronary angiography and the test results was good were recruited as control group.The serum lipids,cystatin C concentrations were tested,and the rela-tionship between the number of coronary lesions,Gensini score and cystatin C concentrations were analyzed.The risks of major car-diovascular events in different cystatin C concentration groups were analyzed.Results Cystatin C concentrations of ACS group were significant higher than control group (P <0.05).Cystatin C concentrations were significantly different among patients with different number of diseased branches(P <0.05).The patients with higher number of diseased branches were with higher concen-tration of cystatin C.There was a positive correlation between cystatin C concentration and Gensini score (r=0.84,P <0.05).The risk of major cardiovascular events in high cystatin C concentration group within 1 year after PCI treatment increased significantly compared with control group,the OR values were 16.63(95%CI :3.87-71.49,P <0.05).Conclusion Cystatin C correlated with the severity of coronary artery disease and the occurrence of major cardiovascular events within one year after PCI treatment.
