The correlation between HLA-DRB71 allele and primary biliary cirrhosis of Han population in Qinghai plateau
10.3969/j.issn.1673-4130.2014.17.014
- VernacularTitle:青海高原汉族人群 HLA-DRB71等位基因与原发性胆汁性肝硬化的相关性研究
- Author:
He YIN
;
Jun LI
;
Qiong WANG
;
Tong LIU
- Publication Type:Journal Article
- Keywords:
human leukocyte antigen;
allele;
primary biliary cirrhosis;
liability
- From:
International Journal of Laboratory Medicine
2014;(17):2303-2304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between HLA-DRB71 allele and primary biliary cirrhosis(PBC)of Han pop-ulation in Qinghai plateau.Methods 95 PBC patients from March 2011 to March 2013 in the hospital were enrolled in the study (PBC group),203 cases of healthy individuals were recruited as control group.By using a sequence specific primer PCR method,the HLA-DRB71 alleles in the two groups were analyzed.Results HLA-DRB71*07 gene frequencies in PBC group and control group were 36.84% and 13.79% respectively,the difference was statistically significant(P <0.05).In PBC group,the other HLA-DRB71 alleles′frequency were lower than that in control group(P <0.05).There was a higher positive rate of HLA-DRB71 * 07 in PBC group than control group,and the OR value is 2.67(P <0.05).All the PCB patients carring HLA-DRB71 *07 alleles were HLA-DRB71*0701,but other subtypes such as HLA-DRB71 *0703,HLA-DRB71 *0704,HLA-DRB71 *0705,HLA-DRB71 *0706 were not found.Conclusion PBC Susceptibility might associated with HLA-DRB71 *0701 alleles,but is not an independent risk factor.
