The tests and correlation analysis of HBV-DNA and hepatic fibrosis indicators in chronic hepatitis B patients
10.3969/j.issn.1673-4130.2014.17.018
- VernacularTitle:慢性乙型肝炎患者 HBV-DNA 水平与肝纤维化相关指标的检测与相关性分析
- Author:
Jiming HAN
;
Ling YANG
- Publication Type:Journal Article
- Keywords:
DNA,hepatitis B virus;
hepatic fibrosis;
chronic hepatitis B
- From:
International Journal of Laboratory Medicine
2014;(17):2311-2312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum HBV-DNA content and hepatic fibrosis indicators in hchronic epatitis B patients.Methods Serum HBV-DNA content was determined by using real-time fluorescence quantitative PCR and he-patic fibrosis indicators including hyaluronic acid,laminin,procollagen Ⅲ,and collagen Ⅳ which were determined by using chemilu-minescence.Results The logarithm value of serum HBV-DNA content of the 110 hepatitis B patients was 5.32±1.37.Serum hyal-uronic acid concentration was (197.81 ±85.37)mg/mL;procollagen Ⅲ concentration was (142.66 ±30.28)μg/mL.Collagen Ⅳconcentration was (90.34 ±20.53)μg/mL.Laminin was (143.96 ±31.79 )μg/mL.All these indicators were significantly higher than the control group (P <0.01).But there were no significant linear correlation between serum HBV-DNA content and the four hepatic fibrosis indicators(P >0.05).Conclusion The hepatic fibrosis indicators increased significantly in hepatitis B patients but there were no significant correlations between serum HBV-DNA content and the hepatic fibrosis indicators.
