Villus cell culture and its karyotype analysis for 112 women who had spontaneous abortion in early pregnancy
10.3969/j.issn.1673-4130.2014.17.022
- VernacularTitle:112例妊娠早期自然流产患者绒毛细胞培养及核型分析
- Author:
Yuantiao LI
;
Yan ZOU
;
Yong LI
- Publication Type:Journal Article
- Keywords:
villus cells;
karyotype;
spontaneous abortion
- From:
International Journal of Laboratory Medicine
2014;(17):2319-2320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical relationship between villus cells chromosome abnormality and spontaneous a-bortion in early pregnancy.Methods Villus cells from 112 women who just had spontaneous abortion in early pregnancy were cul-tured and prepared for karyotype analysis.Results 105 specimens were anaIyzed successfully which accounted for 93.75%(105/112).Among them 50 specimens were normal karyotype which accounted for 47.62%(50/105),55 cases were abnormal karyotype accounted for 52.38%(55/105).Abnormal number was the major type of abnormal karyotype.Among them there were 33 cases of trisomy which were most common,6 cases of triploid,1 case of tetraploid and 1 case of compound,2 cases of chimera,1 case of sex-ual chromatids and 6 cases of structural abnormalities.In the specimens with normal karyotype,20 cases were from male,30 cases were from female.Conclusion Embryo chromosome abnormality is one of the factors causing early pregnancy spontaneous abor-tion.Conduct villus chromosome examination in clinical treatment is useful to determine the reasons of abortion and to guide the next pregnancy.
