Application of thrombus precursor protein and plasma D-dimer in anticoagulation monitoring after mechanical heart valve replacement
10.3969/j.issn.1005-6483.2014.09.022
- VernacularTitle:心脏瓣膜置换术后血栓前体蛋白、D-二聚体在抗凝监测中的应用
- Author:
Jun ZHANG
;
Junzhe WAN
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
prosthetic heart valve implantation;
thrombus precursor protein;
D-dimer;
anticoagulation monitoring
- From:
Journal of Clinical Surgery
2014;(9):682-684
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the values and relationship among the contents of thrombus precursor protein(TpP)and plasma D-dimer(D-D),complications after mechanical heart valve replace-ment and their correlation with international normalized ratio(INR)in anticoagulation therapy and monito-ring.Methods A total of 150 patients with mechanical heart valve replacement were enrolled.TpP,D-D, INR,other indicators and complications were compared to draw conclusions.Results There were signifi-cant differences in TpP among the groups(P<0.0083).Significant differences in D-D among the postop-erative group(100.96 ±61.56),thrombosis group(17.78 ±5.94)and control group(5.97 ±1.58)were observed(P<0.0083).Significant differences in INR among the postoperative group(1.65 ±0.34),hem-orrhage group(2.22 ±0.65)and control group(1.11 ±0.10)were observed(P<0.0083),but the effec-tiveness of INR monitoring for determining the state of thrombosis was limited to a certain extent.Conclu-sion TpP and D-D examination can facilitate monitoring after mechanical heart valve replacement,and it has a certain guiding significance for determining anticoagulation therapy and monitoring of complications after mechanical heart valve replacement.
