The possible relationship between thioredoxin-interacting protein and the pathogenesis of type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2014.08.011
- VernacularTitle:硫氧还蛋白相互作用蛋白与糖尿病致病机制关系的探讨
- Author:
Yali WU
;
Min LONG
;
Xuecui ZHANG
;
Lixia LYU
;
Jinlin WU
;
Fang JIA
;
Dongfang LIU
- Publication Type:Journal Article
- Keywords:
Thioredoxin-interacting protein;
Interleukin-1β;
Diabetes mellitus,type 2;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
2014;(8):682-685
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the plasma thioredoxin-interacting protein ( TXNIP ) levels in different glucose tolerance groups and discuss the relationship between TXNIP and insulin resistance/β-cell dysfunction in diabetes and prediabetes, and to investigate the potential relationship between TXNIP and interleukin-1β( IL-1β) . According to oral glucose tolerance test, 93 participants were divided into 3 groups:diabetes mellitus group, prediabetes group, and normal glucose tolerance group. Plasma TXNIP, IL-1β, and other biochemical indices were measured. The relationship between TXNIP and glucose, IL-1β, homeostasis model assessment for insulin resistance ( HOMA-IR) , and homeostasis model assessment forβcell function ( HOMA-β) were analyzed by using multiple linear regression techniques and Pearson’s linear correlation analysis. Plasma TXNIP level was higher in prediabetes group compared with normal glucose tolerance group, but lower in prediabetes group compared with diabetes mellitus group[(355. 35±31. 88 vs 274. 36±33. 86, 426. 16±63. 15)pg/ml, P<0. 01 or P<0. 05]. TXNIP was positively correlated with IL-1βand HOMA-IR, but negatively correlated with HOMA-β. Multiple linear regression analysis indicated that IL-1βexerted significant influence on TXNIP ( P<0. 05 ). Plasma TXNIP level is affected by blood glucose concentration. There is a close relationship between TXNIP and IL-1β. In prediabetes patient, the TXNIP levels have already been raised.
