Application of vitamin D in the treatment of patients with chronic obstructive pulmonary disease
10.3969/j.issn.1673-4130.2014.17.021
- VernacularTitle:维生素D在慢性阻塞性肺疾病患者治疗中的应用
- Author:
Lixin TANG
;
Yan ZHANG
;
Qiaoying YUAN
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary diseases;
pulmonary function test;
vitamin D;
blood gas analysis;
C reactive protein
- From:
International Journal of Laboratory Medicine
2014;(17):2317-2318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of vitamin D on pulmonary function in patients with chronic obstructive pulmona-ry disease,and to explore its possible mechanism.Methods Patients with chronic obstructive pulmonary disease admitted in the hospital were randomly divided into 2 groups,one group of patients were given regular COPD treatment (control group,30 cases), the other group of patients were given vitamin D on the basis of conventional therapy(experimental group,30 cases).Pulmonary function test and C reaction protein (CRP)determination in the 2 groups were performed,the contents of PaO2 ,PaCO2 were also determined.Results Compared with the control group,lung function improvement in experimental group were more obvious,and the the number of acute attack significantly reduced(P <0.05).The concentration of CRP in experimental group was significantly lower after treatment than before treatment(P <0.05),while the concentration of CRP in control group didn′t change significantly (P >0.05).Conclusion Vitamin D contributes to the improvement of pulmonary function in patients with COPD,and its mecha-nism might relate to the reduction of inflammatory reaction.
