Epigenetic regulation of androgen receptors in prostate cancer
10.3969/j.issn.1000-8179.20141146
- VernacularTitle:前列腺癌中雄激素受体的表观遗传学研究进展
- Author:
Zhiqun SHANG
;
Yuan MA
;
Jing TIAN
;
Ruifa HAN
;
Yuanjie NIU
- Publication Type:Journal Article
- Keywords:
androgen receptor;
epigenetics;
hypermethylation;
castration resistant prostate cancer
- From:
Chinese Journal of Clinical Oncology
2014;(16):1057-1060
- CountryChina
- Language:Chinese
-
Abstract:
The androgen receptor (AR), a nuclear hormone and transcription factor, is the most therapeutic relevant target in pros-tate cancer (PCa) and in the castration-resistant prostate cancer (CRPC). Significant efforts have been focused on understanding the mechanisms involved in the development and progression of CRPC. Recent work has revealed the importance of epigenetic events in-cluding the regulation of AR signaling by methylation, acetylation, and non-coding RNA in the tumorigenesis and development of PCa. We summarize recent findings on the mechanisms of epigenetic regulation of AR signaling in PCa.
