Research progress of autophagy in gastric cancer
10.3969/j.issn.1000-8179.20140297
- VernacularTitle:细胞自噬在胃癌中的相关研究进展
- Author:
Xingming XIE
;
Jingyu DENG
;
Han LIANG
- Publication Type:Journal Article
- Keywords:
autophagy;
gastric cancer;
Beclin-1;
LC3
- From:
Chinese Journal of Clinical Oncology
2014;(16):1061-1064
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is the process through which cells utilize lysosomal hydrolases to degrade cytoplasmic misfolded proteins and damaged organelles. This process allows cells to reuse degradation products and degrade harmful substances to maintain intracellu-lar stability. The autophagy level is low at the normal cell state. Cells under unfavorable conditions activate autophagy to eliminate ad-verse factors. An increasing number of studies have shown that autophagy plays important roles in tumorigenesis, tumor progression, metastasis, relapse, and drug resistance. However, the detailed mechanisms remain unclear. This review summarizes the expression of gastric cancer cell-related autophagy genes and the mechanism by which autophagy promotes gastric cancer cell death. Autophagy has an important application prospect in treating gastric cancer.
