Research progress of BARD1 in tumors
10.3760/cma.j.issn.1006-9801.2014.07.022
- VernacularTitle:BARD1蛋白在肿瘤中作用的研究进展
- Author:
Lin CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
BARD1;
Breast cancer susceptibility gene 1
- From:
Cancer Research and Clinic
2014;26(7):497-499
- CountryChina
- Language:Chinese
-
Abstract:
BRCA1-associated RING domain 1(BARD1) is composed with ring finger,ankyrin repeats and BRCT (BRCA1 C-terminus) domain.The special structure is involved in many essential biological processes such as DNA repair,cell survival and apoptosis,proteasome dependent protein degradation and so on.The abnormal expression of BARD1 is closely related with the occurrence and progression of carcinoma.Aberrant splice variants of BARD1 are very potential tumor markers for cancer diagnosis.
