Application of 9. 4 T of DTT in the diagnosis of cerebral gliomas of SD rat
- VernacularTitle:9.4 T磁共振弥散张量纤维束成像对SD大鼠C6胶质瘤模型肿瘤生长特点随时间变化的影像学分析
- Author:
Lu MA
;
Yongqiang YU
- Publication Type:Journal Article
- Keywords:
9 . 4 T;
DTT;
DTI;
MRI;
C6 model of Glioma;
SD rat;
FA values
- From:
Acta Universitatis Medicinalis Anhui
2014;(9):1233-1237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the 9 . 4 T of DTT in the diagnosis of SD rat C6 cerebral gliomas model about the change of CST on tumor progression and pathology confirmed. Methods ①10 μl C6 cell suspension of 106 cells number were implanted into the right caudate nucleus of brain hemisphere of 20 adult male SD rat with ster-eotactic technique. ②Application of 9. 4 T of DTT and DTI, meanwhile the routine T1-weighted imaging(T1WI), T2-weighted imaging(T2WI), contrast-enhanced T1WI,FLAIR imaging and diffusion tensor of the brain were ac-quired. Anatomic relationship between cerebral glioma and surrounding white matter fiber tracts was analyzed and measured the values of FA and MD in different areas on fractional anisotropic ( FA) map, color-coded directional map, three-dimensional (3D) white matter fiber tracts map, then stained with routine HE. Results All of SD rat C6 cerebral gliomas models 3 D white matter fiber tracts map by means of FA maps of DTI were successfully comple-ted. Apparently significant differences of FA values were found in solid tumor, surrounding edema, compared with normal white matter regions ( P<0.05 );but there was no significant difference among solid tumor and surrounding edema region (P>0.05);there were significant differences of MD values between solid tumor, surrounding edema and normal white matter region ( P<0.05 ) . Conclusion The 9 . 4 T of DTT offers the optimal visualization of An-atomic relationship between cerebral glioma and surrounding white matter fiber tracts in the different periods of the tumor moder.
