Relationship Between Framingham Risk Score for Coronary Artery Disease and Cognitive Function in Healthy Community Elders
10.3969/j.issn.1000-3614.2014.08.016
- VernacularTitle:社区健康老年人的弗明汉评分与认知功能的关系研究
- Author:
Wei WANG
;
Yu HOU
;
Zhipeng TIAN
;
Linan LIU
;
Xueying ZHOU
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Cognitive function;
Elders;
Risk factor;
Framingham risk score
- From:
Chinese Circulation Journal
2014;(8):620-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between Framingham risk score for coronary artery disease (CAD) and cognitive function in healthy community elders.
Methods: A total of 276 healthy community elders were evaluated by Framingham score to predict the risk for suffering from CAD in 10 years. The subjects were divided into 3 groups. High risk group (the risk > 20%), n=46, Mid risk group (the risk at 10%-20%), n=76 and Low risk group (the risk < 10%), n=154. The cognitive function was measured by mini-mental state examination (MMSE) and China adult intelligence scale (CISA). The differences of cognitive function levels to 3 CAD risk groups were studied.
Results: With the increased CAD incidence from Low risk, Mid risk to High risk groups, the MMSE score reduced accordingly (26.9 ± 1.45) vs (24.3 ± 1.53) vs (22.2 ± 1.43), P=0.014. Pearson analysis presented that MMSE score was negatively related to Framingham risk score (r=-0.213, P<0.001). There were several elements of cognitive function related to Framingham risk score including MMSE score, question answering, grid filling, oral arithmetic and word distinguishing (r=-0.247), (r=-0.167), (r=-0.132), (r=-0.152) and (r-0.256), all P<0.05.
Conclusion: CAD risk level was negatively related to cognitive function, the higher Framingham risk score resulted in the lower cognitive function in healthy community elder subjects.
