Clinical study of different doses of intracoronary adenosine on the measurement of fractional flow reserve
10.3969/j.issn.1004-8812.2014.08.003
- VernacularTitle:冠状动脉内注射不同剂量腺苷测定冠状动脉血流储备分数的临床研究
- Author:
Shaosheng LI
;
Jie DENG
;
Xin ZHAO
;
Yana SHI
;
Xiaozeng WANG
- Publication Type:Journal Article
- Keywords:
Adenosine;
Fractional flow reserve;
Coronary disease;
Coronary angiography
- From:
Chinese Journal of Interventional Cardiology
2014;(8):488-491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the suitable dose of intracoronary adenosine (AD) on fractional flow reserve (FFR) measurement in Chinese patients with angiographic coronary artery disease. Methods FFR was measured in 32 patients with 40 moderate coronary stenosis. Boluses of intracoronary AD at increasing doses of 60μg (A1), 80μg (A2), 100μg (A3) and 120μg (A4) were randomly administered. FFR values, symptoms, systemic effects and development of atrioventricular block were recorded. Results FFR value decreased significantly by 8.99%(A1), 11.24%(A2), 13.48%(A3) and 13.48%(A4) compared with the baseline distal coronary pressure/aortic pressure (0.891±0.044, all P<0.001). A3 and A4 showed significantly lower FFR values than A1 (t=6.331、6.343, all P < 0.001),A2 (t=2.974、3.058, P=0.005、0.004). Positive rates of an FFR of<0.75 were 30.0%(n=12), 32.5%(n=13), 35.0%(n=14) and 35.0%(n=14) in A1, A2, A3 and A4. A total of 13 patients(40.6%) reported at least one side effects. Conclusions This study suggests a dose-response relationship for intracoronary AD on the measurement of FFR in Chinese patients with angiographic coronary artery disease. The suitable dose of bolus of intracoronary AD is 100μg.
