Correlation between PPARγand coronary stenosis and plaque stabilit of patients with ACS and T2DM
10.3969/j.issn.1004-8812.2014.08.005
- VernacularTitle:急性冠状动脉综合征合并2型糖尿病患者血浆过氧化物酶体增殖物激活受体γ与冠状动脉病变严重程度及斑块稳定性的相关性研究
- Author:
Qing SUN
;
Xiaoyan LI
;
Juan LIU
;
Hongming ZHANG
;
Guoming ZHANG
;
Shufang HAN
;
Yingjian CHEN
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
T2DM;
PPARγ;
MMP-9;
Gensini scores
- From:
Chinese Journal of Interventional Cardiology
2014;(8):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of PPARγ in acute coronary syndrome (ACS) patients with type 2 diabetes (T2DM) for the severity of coronary atherosclerosis and plaque stability. Methods We selected 102 patients with ACS, including 52 patients with type 2 diabetes mellitus (ACS+T2DM group) and 50 patients with simply ACS (ACS group). Meanwhile, we selected 30 patients without coronary heart disease and T2DM as the control group. All basic clinic data, CAG and the Gensini score were compared among all groups. To all patients, blood was drew when they were enrolled to detect the level of PPARγ and MMP-9. Results Gensini points in the ACS+T2DM group was much higher than that of the ACS group (P < 0.05). The levels of PPARγ of the ACS group and the ACS+T2DM group, when compared with the control group, were decreased significantly, but the level of MMP-9 were increased (all P < 0.05). The level of PPARγ in the ACS+T2DM group was much lower than the ACS group, and the level of MMP-9 was much higher (P<0.05). Gensini scores (r=-0.416, P<0.05), the level of MMP-9(r= - 0.503, P < 0.05) were correlated negatively with the level of PPARγ. Conclusions Complicating with T2DM can aggravate coronary artery disease and plaque instability degree in ACS patients, and PPARγpossibly make an protective effect.
