The polymorphism of HLA-DRB1/DPB1 in multiple sclerosis and optica neuromyelitis patients
10.3936/j.issn.1002-0152.2014.07.004
- VernacularTitle:多发性硬化与视神经脊髓炎患者的HLA-DRB1/DPB1基因多态性
- Author:
Yongqiang DAI
;
Jin LI
;
Aimin WU
;
Jian BAO
;
Zhengqi LU
;
Xueqiang HU
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Neuromyelitis optica;
Human leucocyte antigen;
Polymorphism;
Haplotype
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(7):400-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of the polymorphism of HLA-DRB1/DPB1 in patients with multiple scle-rosis (MS) and optica neuromyelitis (NMO). Methods Fifty-three patients with MS, 30 patients with NMO and 93 normal controls were enrolled in the present study. The HLA-DRB1/DPB1 gene polymorphism and allele frequencies were deter-mined by sequencing-based typing. All the subjects were Southern Han Chinese and were born in Southern China. Re-sults The frequencies of DPB1*0501 were higher in NMO patients than in controls, P=0.001, P (corrected)=0.022. The frequencies of DRB1*1602 DPB1*0501 haplotype were higher in NMO patients than in MS patients, P<0.001,P (cor-rected)=0.040. Conclusions There is significant difference in HLA-DRB1/DPB1 gene polymorphism between MS and NMO patients in a Southern Han Chinese population. The HLA-DPB1*0501 allele might be the susceptibility gene poly-morphism of NMO.
