Predictive value of serum cTnI and NT-proBNP for patients with chronic stable heart failure
10.3969/j.issn.1008-0074.2014.04.12
- VernacularTitle:血清 cTnI 和 NT-proBNP 对稳定性慢性心衰病人的预测价值
- Author:
Yong ZHAO
;
Qingqing CHEN
;
Feng GUO
;
Zhengyan ZHU
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Natriuretic peptide,brain;
Troponin I
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(4):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation among serum cardiac troponin I (cTnI),N terminal pro brain natri-uretic peptide (NT-proBNP)and main endpoint events of heart in patients with chronic stable heart failure.Meth-ods:The present study enrolled 95 patients with NYHA cardiac function class III~IV from Feb 2010 to Feb 2011.According to levels of cTnI and NT-proBNP,the patients were divided into cTnI negative group (n=60)and cTnI positive group (n=35);NT-proBNP negative group (n=40)and NT-proBNP positive group (n=55),all patients were followed up for two years,and the main endpoint events were cardiogenic sudden death and rehospitalization caused by acute aggravation of heart failure.Results:Compared with negative group,the hazard ratio (HR)of end-point events was 2.69 and confidence interval (CI)was 1.54~ 4.72,P = 0.002 in cTnI positive group;HR was 2.54 and CI was 1.35~4.78,P =0.003 in NT-proBNP positive group;further interclass crossover analysis found that,when patients'cTnI and NT-proBNP were both positive,the hazard ratio of cardiac endpoint events was the highest (HR=6.34,CI 2.26~17.9,P <0.001).Conclusion:In patients with chronic stable heart failure,serum elevated levels of cardiac troponin I and N terminal pro brain natriuretic peptide are important predictors reflecting prognosis of patients with heart failure.
