Updated nuclear export mechanism and significance of Nrf2
- VernacularTitle:Nrf2出核转运机制及意义的研究进展
- Author:
Jiaxiang DUAN
;
Jiaolin NING
;
Kaizhi LU
- Publication Type:Journal Article
- Keywords:
Nrf2;
Nuclear export;
Oxidant stress
- From:
Journal of Medical Postgraduates
2014;(8):874-877
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-E2-related factor 2(Nrf2)is a member of C′n′C transcription factor family.It is an important transcrip-tion factor for regulation of cellular redox status and can be seen in all kinds of tissues .Recent studies have demonstrated that rapid deg-radation of Nrf2 after gene-induced antioxidative stress is as important as transcription and activation of Nrf 2 and the nuclear export of Nrf2 is a prerequisite for rapid degradation of Nrf2 in the cytosol.This review focuses on the mechanism of nuclear export of Nrf 2.
