Solubilization of Sulfobutyl Ether-β-cyclodextrin on Voriconazole
- VernacularTitle:磺丁基醚-β-环糊精对伏立康唑增溶作用的考察
- Author:
Xian XIU
;
Wei TIAN
;
Dongjian CHEN
;
Xiaoyan ZHANG
;
Caixia FENG
;
Yanhui LI
- Publication Type:Journal Article
- Keywords:
Voriconazole;
Sulfobutyl ether-β-cyclodextrin;
Stability constant;
Stability
- From:
China Pharmacist
2014;(9):1457-1460
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To research the solubilization of sulfobutyl ether-β-cyclodextrin ( SEB-β-CD) on voriconazole and the sta-bility of voriconazole with different pH values. Methods:Phase-solubility diagram was applied to study the solubilization of SEB-β-CD on voriconazole. Meanwhile, the impurity of voriconazole was determined to study the stability. Results:SBE-β-CD could increase the solubility of voriconazole significantly and the apparent stability constant was similar within the pH range of 5. 0-8. 0. The stability of voriconazole was decreased with the increase of pH. Conclusion:SEB-β-CD is an ideal solubilizer for voriconazole, while the stability is influenced by pH.
