Preparation and in vitro Dissolution of Pioglitazone Hydrochloride Sustained-release Pellet Capsules
- VernacularTitle:盐酸吡格列酮缓释微丸胶囊制备及体外释放特性
- Author:
Yingying WANG
;
Xingang CUI
;
Hongxuan CHEN
- Publication Type:Journal Article
- Keywords:
Pioglitazone hydrochloride;
Fluidized-bed;
Pellets;
Sustained-release;
Coating
- From:
China Pharmacist
2014;(9):1503-1505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare pioglitazone hydrochloride ( PGH) sustained-release pellet capsules and study the in vitro disso-lution. Methods:The preparation was prepared with a bottom spray fluidized bed, and the formula and technology were optimized by orthogonal test. Results:The method was simple and easy to operate, the reproducibility of the formula and technology was good, and the pellets had obvious sustained-release property. Conclusion:The formula and technology are easy and controllable, and the stability of sustained release pellets is good.
