Effectiveness and Recurrence Prevention of Esomeprazole at Various Doses in Patients with Reflux Esoph-agitis
- VernacularTitle:不同剂量埃索美拉唑维持治疗反流性食管炎的疗效及预防复发作用观察
- Author:
Yong DING
;
Bojun WANG
- Publication Type:Journal Article
- Keywords:
Reflux esophagitis;
Esomeprazole;
Proton pump inhibitor;
Recurrence;
Maintenance treatment
- From:
China Pharmacist
2014;(9):1526-1528
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effectiveness and recurrence prevention of esomeprazole at different doses in the patients with reflux esophagitis ( RE) . Methods:Totally 240 patients with RE were divided into mild or severe group with 120 cases in each accord-ing to the illness severity. The two groups were respectively divided into four groups according to the random number table, namely the full dose treatment group, half dose treatment group, intermittent treatment group and on-demand treatment group. The groups were fol-lowed up for 6 months, and GERD-HRQI scores, the recurrence rate and incidence of adverse reactions in all the groups were com-pared. Results:After the 6-month follow-up, the differences in the GERD-HRQI scores, recurrence rate and incidence of adverse re-actions among the groups with different doses were statistically significant (P<0. 05). The GERD-HRQI scores and RE recurrence rate in on-demand treatment group were significantly higher than those in the other groups(P<0. 05), and the incidence of adverse re-actions in the total dose treatment group was significantly higher than that in the other groups (P<0. 05). Conclusion: Intermittent treatment with esomeprazole at small dose can effectively prevent RE recurrence, reduce the incidence of adverse reactions and treat-ment costs, which is worthy of promotion.
