Effects and mechanisms of bevacizumab-induced renal impairment

VernacularTitle:贝伐珠单抗肾脏损害作用及机制
Author: Yi HE ; Qunhong XU ; Xueqin CHEN ; Yuelong PAN ; Ming WANG
Publication Type:Journal Article
Keywords: Bevacizumab; Renal impairment; Proteinuria; Renal pathology
From: Journal of International Oncology 2014;(8):602-605
CountryChina
Language:Chinese
Abstract: Bevacizumab has been widely used in tumor targeting therapy,while the most common adverse reaction is renal impairment,manifested as proteinuria. The main mechanisms may include interfering podocytes-endothelial vascular endothelial growth factor(VEGF)axis signals,increasing glomerular pressure caused by secondary hypertension,subacute renal thrombotic microangiopathy caused by endothelial damage and so on. Thrombotic microangiopathy is the main renal pathological type,and other rare types include glomer-ular lesions,renal interstitial disease,and benign renal arteriolar nephrosclerosis. Therefore,urine protein excretion and renal function should be closely monitored during bevacizumab treatment period for timely treat-ment,dose reduction or even withdrawal if necessary to ensure renal function.