Expression of Y-box-binding protein-1 and epithelial-mesenchymal transition markers in colorectal cancer
10.3760/cma.j.issn.1673-422X.2014.08.020
- VernacularTitle:Y盒结合蛋白1与上皮-间质转化标志物在结直肠癌中表达的研究
- Author:
Xuebing YAN
;
Leilei YAN
;
Sihong LIU
;
Zezhi SHAN
;
Zhiming JIN
- Publication Type:Journal Article
- Keywords:
Y-box-binding protein 1;
Colorectal neoplasms;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2014;(8):624-628
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of Y-box-binding protein-1(YB-1)and epithelial-mesenchymal transition(EMT)markers(E-cadherin and N-cadherin)in colorectal cancer(CRC),to analyze the relationship between the expression of YB-1 and clinicopathological parameters,to evaluate the correlations among YB-1,E-cadherin and N-cadherin. Methods The expressions of YB-1,E-cadherin and N-cadherin in 120 primary CRC tumors and corresponding normal tissues were detected by western blot and immunohistochem-istry and the results were analyzed. Results The expressions of YB-1,E-cadherin and N-cadherin in tumors were significantly different from those in corresponding normal tissues(χ2 = 47. 373,P ﹤ 0. 05;χ2 = 83. 145, P ﹤ 0. 05;χ2 = 41. 832,P ﹤ 0. 05). The expression of YB-1 in tumors was associated significantly with tumor differentiation,tumor invasion,lymph node metastasis and distance metastasis(χ2 = 8. 077,P = 0. 008;χ2 =8. 178,P = 0. 006;χ2 = 15. 152,P ﹤ 0. 001;χ2 = 7. 368,P = 0. 011). It was negatively correlated with E-cadherin expression(r = - 0. 238,P = 0. 009),but positively correlated with N-cadherin expression(r =0. 361,P ﹤ 0. 001). Conclusion YB-1 may promote the occurrence and development of CRC by participating in EMT program.
