Therapeutic effect of increasing dose of metoprolol by rapid titration method on acute myocardial in-farction
10.3969/j.issn.1008-0074.2014.04.23
- VernacularTitle:快速滴定法加量美托洛尔治疗急性心肌梗死的疗效
- Author:
Shaowei CHEN
;
Zhishan SUN
;
He HUANG
;
Mingxing WU
;
Yi ZHOU
- Publication Type:Journal Article
- Keywords:
Titrimetry;
Myocardial infarction;
Metoprolol
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(4):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe and compare the therapeutic effect of metoprolol by routine increasing dose method and rapid titration method on acute myocardial infarction (AMI).Methods:A total of 60 inpatients,who were di-agnosed with AMI within 24h and without contraindications for metoprolol,were randomly divided into two groups:routine therapy group (received metoprolol using routine methods,the dose was added in seven days)and rapid ti-tration group (metoprolol was added in three days using titration).The dosage maintained with 190 mg/d after both groups reaching the target dose of 190mg/d;then therapeutic effects were observed in both groups.Results: ①There were no re-myocardial infarction,rehospitalization caused by heart failure and sudden death etc.in both groups;② Patients received echocardiography in outpatients after three months.Compared with routine increasing dose group,there was significant reduction in left ventricular end-diastolic diameter [LVEDd,(55.00±7.56)mm vs.(50.00± 5.81)mm]and significant rise in left ventricular ejection fraction [LVEF,(49.13 ± 10.18)% vs. (57.84±10.34)%]in rapid titration group,P <0.01 both.Conclusion:Rapid titration method could make the pa-tients rapidly reach the targeted dose of metoprolol and inhibit renin release earlier,block the renin-angiotensin sys-tem,and improve myocardial remodeling and cardiac function.
