Determination of ALDH2 Polymorphism in Chinese by Gene Chip
- VernacularTitle:基因芯片法检测中国人乙醛脱氢酶2的基因多态性
- Author:
Yumei WANG
;
Junfen XING
;
Tao WANG
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Nitroglycerin;
ALDH2;
Polymorphism;
Rational drug use
- From:
China Pharmacist
2014;(9):1447-1450
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the polymorphism of ALDH2 gene in Chinese and to guide the rational use of nitroglycerin. Meth-ods:The polymorphism of ALDH2 (Glu504Lys) was measured by colorful gene chip. Results:The polymorphism of ALDH2 from 1026 clinical samples in China was detected by gene chip. The results showed that there were three genotypes. The distribution of the three genotypes of wild type [ALDH2(504Glu)], heterozygotes [ALDH2(Glu504Lys)] and homozygous mutant [ALDH2(504Lys)] was 61. 7%(623 samples), 31. 6%(319 samples) and 6. 6%(67 samples), respectively. Conclusion:Approximately one third of Chinese patients can not be treated by nitroglycerin. The gene detection method in the study is suitable for the guide of rational drug use in hospi-tal.
