Preparation and Properties in vitro of Sirolimus Dropping Pills
- VernacularTitle:西罗莫司滴丸的研制及其体外性质考察
- Author:
Ling SONG
;
Yongjun HU
;
Shaoting LI
;
Wen HE
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Dropping pills;
Properties in vitro
- From:
China Pharmacist
2014;(9):1466-1469
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare sirolimus ( SRL) dropping pills to improve SRL solubility and dissolution. Methods:The base of SRL dropping pills was screened. The optimal formula and preparation process were also optimized by orthogonal design. The equi-librium solubility, hygroscopicity and drug release in vitro of SRL dropping pills were studied. Results: PEG6000 was chosen as the base. The optimal preparation conditions of SRL dropping pills were as follows: the ratio of SRL and base was 1∶10, the dropping speed was 65 drops/min, the dropping temperature was 95℃ and the temperature of cooling solvent was 5℃. The equilibrium solubili-ty of SRL dropping pills in different solvents was increased significantly compared with that of SRL. The hygroscopicity of the dropping pills was notable. The drug release in vitro of SRL dropping pills was similar to that of the marketed tablets with quick and complete re-lease. Conclusion:SRL dropping pills exhibit increased solubility and improved dissolution, which are valuable to be studied further.
