Expression and therapy of Prame gene on hematologic malignancies
10.3760/cma.j.issn.1673-422X.2014.08.017
- VernacularTitle:Prame 基因在血液恶性肿瘤中的表达与治疗
- Author:
Zhaoyun LIU
- Publication Type:Journal Article
- Keywords:
Hematologic neoplasms;
Immunotherapy;
Preferentially expressed antigen of melanoma
- From:
Journal of International Oncology
2014;(8):611-614
- CountryChina
- Language:Chinese
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Abstract:
As a member of the family of cancer-testis antigen,preferentially expressed antigen of mela-noma(Prame)can improve the proliferation of tumor via inhibiting the retinoic acid receptor signal path and impeding the transcription factor which is a wide range of physiological processes in development and differentia-tion of tumor cells. Prame expresses in solid tumors and hematological malignancies,which is widely used for tumor diagnosis,monitoring of tumor metastasis and immunotherapy.
