Diagnostic value of serum procalcitonin in pulmonary tuberculosis compli-cated with pulmonary infection
10.3969/j.issn.1671-9638.2014.08.009
- VernacularTitle:血清降钙素原在肺结核合并肺部感染诊断中的应用
- Author:
Zhenhua CHEN
;
Xiao TAN
;
Yanyan YU
;
Yunhong TAN
- Publication Type:Journal Article
- Keywords:
pulmonary tuberculosis;
Mycobacterium tuberculosis;
bacteria;
fungus;
procalcitonin;
diagnosis
- From:
Chinese Journal of Infection Control
2014;(8):482-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical significance of serum procalcitonin (PCT)in early diagnosis of pul-monary tuberculosis (PTB)complicated with pulmonary infection.Methods Clinical data of active PTB patients admitted to a hospital between August and December 2013 were collected,patients were divided into bacterial infec-tion group(n=104),fungal infection group(n=37)and control group (n=95)according to whether patients were associated with bacterial infection,fungal infection,and without infection,serum PCT concentrations in three groups were compared,receiver operating characteristic (ROC)curve analysis was conducted.Results The median PCT concentrations in bacterial infection and fungal infection group was 0.44ng/mL and 0.30ng/mL respectively, which was significantly higher than 0.16ng/mL of control group(Z =9.49,3.51 respectively,both P <0.001 ).The area under curve (AUC)was 0.89(0.84-0.93)and 0.69(0.61 -0.77)respectively;cut-off point was 0.31 ng/mL and 0.27 ng/mL respectively;sensitivity was 79.81%(70.57%-86.80%)and 59.46%(42.19%-74.80%)respectively;specificity was 83.16%(73.79%-89.78%)and 73.68%(63.48%-81.95%)respectively.Conclusion PCT level is a valuable predictor for early diagnosis of PTB complicated with pulmonary infection,and can provide reference for the rational use of antimicrobial agents.
