Competitiveα-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid receptor antagonists:research advances

VernacularTitle:竞争性α-氨基-3-羟基-5-甲基-4-异唑恶唑丙酸受体拮抗剂研究进展
Author: Dian XIAO ; Lingxiao WANG ; Xinbo ZHOU ; Song LI
Publication Type:Journal Article
Keywords: α-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid; receptor; competitive antagonists; central nervous system
From: Journal of International Pharmaceutical Research 2014;(4):407-412
CountryChina
Language:Chinese
Abstract: α-Amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid (AMPA) receptor, a subtype of ionotropic glutamate receptors widely distributed in the central nervous system, mediates the fast excitatory neurotransmission. Meanwhile more and more evidence indicates that AMPA receptor plays an important role in synaptic plasticity as well as central sensitization, and it also has close relationships with nervous system diseases. Over stimulation of AMPA receptor would produce excitotoxicity, leading to neuronal damage and finally resulting in a multitude of nervous system diseases, such as epilepsy, amyotrophic lateral scelerosis,Parkinson′s dis-ease. Competitive AMPA receptor antagonists that downregulate AMPA receptor′s function are of great importance in the prevention and treatment of nervous system diseases. This article reviews the research advances of competitive AMPA receptor antagonists.