Clinical significance of measurement of plasma Hcy,NOS and STM in acute cerebral infarction

VernacularTitle:急性脑梗死患者检测Hcy、NOS及STM检测的临床意义探讨
Author: Weiping ZHANG ; Jianguo ZHAO ; Jie GENG ; Qi ZHANG ; Genli ZHANG ; Xueqi ZHANG ; Wei YAN ; Guosen LI
Publication Type:Journal Article
Keywords: homocysteine; nitric oxide synthesis; soluble thrombomodulin; acute cerebral infarction
From: International Journal of Laboratory Medicine 2014;(16):2147-2148
CountryChina
Language:Chinese
Abstract: Objective To investigate the level change and the significance of serum homocysteine(Hcy),endothelial nitric oxide synthase(NOS)and soluble thrombomodulin(STM)in the patients with acute cerebral infarction(ACI).Methods The values of serum Hcy,NOS and STM were detected in the 150 patients with ACI and the 50 healthy individuals and the detection results were performed the significance testing and the correlation analysis.Results Compared with the normal control group,the levels of ser-um Hcy,NOS and STM in the ACI patients were significantly increased with statistical differences(P <0.05).The increased level of NOS and HCY in the ACI patients was positively correlated with the increased Hcy level.Conclusion Hcy,NOS and STM are the markers of endothelial injury occurrence and their detection has certain significance for judging the disease condition and guiding treatment.