Application value of combination detection of tumor markers in diagnosis and differential diagnosis of lung cancer
10.3969/j.issn.1673-4130.2014.16.021
- VernacularTitle:肿瘤标志物联合检测在肺癌诊断及鉴别诊断中的应用价值
- Author:
Na LI
;
Guohua LI
- Publication Type:Journal Article
- Keywords:
lung cancer;
tumor markers;
diagnosis
- From:
International Journal of Laboratory Medicine
2014;(16):2171-2173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of 6 kinds of tumor markers serum neuron-specific enolase(NSE),cy-tokeratin 19 fragment(Cyfra21-1),carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 12-5(CA12-5),squamous cell carcino-ma antigen(SCC-Ag),carcino embryonic antigen(CEA)in the diagnosis and differential diagnosis of lung cancer.Methods Serum NSE,Cyfra21-1,CA19-9,CA12-5,SCC-Ag and CEA levels were detected in 140 cases of lung cancer,57 cases of benign lung disea-ses and 45 individuals with healthy physical examination as control group by electrochemiluminescence immunoassay.The values of these 6 kinds of tumor marker in the diagnosis and the differential diagnosis of lung cancer were observed.Results The levels of CA12-5,CA19-9 and CEA in the lung cancer group were significantly higher than those in the benign lung diseases group and the healthy physical examination group(P <0.05 ),the sensitivity and accuracy in the combined detection of the six kinds of tumor marker in diagnosing lung cancer were 95.2% and 89.7% respectively,which was superior to those in single index detection.Con-clusion The tumor makers need to be jointly detected,which can increase the sensitivity and accuracy for diagnosing lung cancer and conduces to the differential diagnosis of early lung cancer.
