Expression of angiopoietin like protein-1,2 and its relationship with angiopathy in type 2 diabetes mellitus
10.3969/j.issn.1673-4130.2014.16.026
- VernacularTitle:血管生成素样蛋白1和2水平在2型糖尿病患者中的表达及与血管病变的关系
- Author:
Li LI
;
Lei QIAN
;
Dexun CHEN
- Publication Type:Journal Article
- Keywords:
angiopoietin like protein;
diabetes mellitus,type 2;
vascular complications
- From:
International Journal of Laboratory Medicine
2014;(16):2183-2184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of angiopoietin like protein-1(Ang-1)and angiopoietin like protein-2(Ang-2)in type 2 diabetes mellitus(T2DM)and its relationship with angiopathy.Methods Ang-1,Ang-2,FBG,FINS and HbA1c were meas-ured in 120 cases of T2DM,including 32 cases of macroangiopathy,52 cases of microangiopathy and 36 cases without angiopathy, and 50 healthy subjects with physical examination were selected as the control group.The detection results were compared between the two groups.Results Compared with control group,the Ang-1 level in the T2DM group was no statistical difference(P >0.05), but the Ang-2 level was significantly higher than that in the control group(t=2.6,P <0.01).The Ang-2 level in T2DM with com-plicating angiopathy was significantly higher than that in T2DM without angiopathy and closely correlated with the blood vessel number of angiopathy.The Ang-2 level in T2DM was significantly positively correlated with HOMA-IR and HbA1c(r=0.577 and 0.509,P <0.01),and there was no correlation between the Ang-1 level and HOMA-IR(P >0.05).Conclusion The Ang-2 level in the patients with T2DM is significantly increased,which is closely related with HbA1c and insulin resistance,furthermore Ang-2 may participate in the generation and development of pathogenesis in T2DM.
