Effects of Ginger Phenol on IL-17 and IL-23 in Serum of Rheumatoid Arthritis Model Rats
10.3969/j.issn.1005-5304.2014.09.013
- VernacularTitle:姜酚对类风湿关节炎模型大鼠血清白细胞介素-17及白细胞介素-23的影响
- Author:
Wukai MA
;
Xueming YAO
;
Ying HUANG
;
Fang TANG
;
Ying WANG
;
Jing ZHOU
- Publication Type:Journal Article
- Keywords:
collagen-induced arthritis;
IL-17;
IL-23;
ginger phenol;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(9):43-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Chinese medicine ingredient ginger phenol on expressions of IL-17 and IL-23 in collagen-induced arthritis (CIA) rats;To investigate the role and mechanism of ginger phenol in CIA rats.Methods Forty female Wistar rats were randomly divided into 4 groups:blank group, model control group, ginger phenol treatment group and tripterygium glucosides control group. After CIA was established in rats successfully, ginger phenol treatment group and tripterygium glycosides control group were treated with ginger phenol and tripterygium glycosides by gavage, while the control group and model control group were fed with the same amount of saline. Four weeks after the treatment, the rats were collected serum and sacrificed. The pathological of CIA joint synovial was observed by electron microscope. The expressions of IL-17 and IL-23 in serum were detected by ELISA.Results The hyperplasia of synovial tissue and angiogenesis was reduced in gingerol phenol treatment group. Infiltration of inflammatory cells and edema was improved. IL-17 and IL-23 expressions of in serum of CIA rats were significantly higher than those of the blank group (P<0.01). Ginger phenol and tripterygium glycosides down-regulated the expressions of IL-23 and IL-17 (P<0.05,P<0.01). Ginger phenol group was better than that of tripterygium glycosides control group (P<0.05).Conclusion Chinese medicine ingredient ginger phenol can reduce expressions IL-17 and IL-23 in serum of CIA rats.
