Study on Anaphylactoid Reaction Induced by Shuanghuanglian Injection
10.3969/j.issn.1005-5304.2014.09.019
- VernacularTitle:双黄连注射液类过敏反应研究
- Author:
Chonggang HUANG
;
Zongcheng MO
;
Silan WU
;
Chaoli LUO
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Shuanghuanglian injection;
anaphylactoid reaction;
serum IgE;
serum histamine
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(9):64-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the anaphylactoid reactions of Shuanghuanglian injection, determine the serum histamine level of sensitized animal, and to investigate its correlation with anaphylactoid reactions.Methods The guinea pigs were randomly selected to observe the anaphylactoid reactions using Shuanghuanglian injections in the different injection speed or different doses, and the serum histamine and the serum IgE of sensitized animals were determined by ELISA. Results The anaphylactoid reactions were induced by Shuanghuanglian injections in the different conditions of injection speed and doses in guinea pigs. There were no obvious difference about the serum IgE level between Shuanghuanglian group and saline group were injected in injection speed and doses. The serum histamine level was significantly increased in Shuanghuanglian group both different conditions of injection speed and doses, and it related to doses and speed. Conclusion Shuanghuanglian injection can cause anaphylactoid reactions in guinea pigs, and the changes of serum histamine level are related to injection speed and doses of Shuanghuanglian injection.
