Dynamic changes of viral loads and antibody responses in ICR mice naturally infected with hepatitis virus
10.3969.j.issn.1671.7856.2014.007.007
- VernacularTitle:ICR 小鼠自然感染小鼠肝炎病毒后抗原抗体的变化
- Author:
Xiangmei LIU
;
Weibo ZHAO
;
Wen YUAN
;
Jing WANG
;
Yue WU
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
Mouse hepatitis virus;
Naturally infected;
Antigen and antibody
- From:
Chinese Journal of Comparative Medicine
2014;(7):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To define dynamic changes of viral loads and antibody responses in ICR mice naturally infected with hepatitis virus in an MHV contaminative facility .Method A total 50 ICR were housed by different “dirty bedding” exposure.Antigen and antibody was detected after 2,4,8,14,21,28,35,42,56 and 84 days.Result Mouse hepatitis virus (MHV) was detected in lung after 2 days, and positive rate is 20% (1/5).MHV was detected in lung, liver, cecal and feces during 4 and 56 days.The positive rate was 0/5 in lung, liver, cecal and feces on 84 days after experiments.Antibody positive rates were 100%during 8 and 84 days.Conclusion Serological method can be used as the main method for the diagnosis of the daily supervision , and antigen detection method can only be applied to early diagnosis .
