Change of coagulation and fibrinolytic function in neonatal sepsis
10.3969/j.issn.1673-4130.2014.16.025
- VernacularTitle:新生儿败血症凝血与纤溶功能变化研究
- Author:
Caizhi HUANG
;
Liya MO
;
Juan YANG
;
Aiguo LI
;
Yongchao DENG
- Publication Type:Journal Article
- Keywords:
sepsis;
antithrombin-Ⅲ;
D-dimer;
platelet
- From:
International Journal of Laboratory Medicine
2014;(16):2181-2182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change and clinical significance of coagulation and fibrinolytic function in neonatal sepsis. Methods 86 neonates inpatients in the neonatology department of our hospital were selected and divided into the ordinary infection group(30 cases)and the sepsis group(56 cases),and 30 healthy neonates were selected as the normal control group.Plasma AT-Ⅲactivity,DD level and PLT count were detected immediately after admission and the detection results were analyzed.Results Com-pared with the control group and the ordinary infection group,the AT-Ⅲ activity and the PLT count in the sepsis group were sig-nificantly decreased,while the DD level was significantly increase,the difference had statistical significance(P <0.01).The differ-ences of the three indexes had no statistical significance between the normal control group and the ordinary infection group(P >0.05);however,the AT-Ⅲ activity and the PLT count in the DIC group were significantly decreased and the DD level was signifi-cantly increased(P <0.01),the occurrence rate of abnormal three indexes was 83.33%(15/18)in the DIC group,which was signifi-cantly higher than that in the non-DIC group(χ2 =17.75,P =0.00).Conclusion The obvious dysfunction of coagulation and fibri-nolysis exists in neonatal sepsis,which is related with the severity degree of disease.The joint detection of AT-Ⅲ activity,DD level and PLT count is helpful for the early diagnosis of DIC in neonatal sepsis.
