Effects of Puerarin on Glucose, Lipid Metabolism and Gastric Motility in Early Period Type 2 Diabetic Rats
10.3969/j.issn.1005-5304.2014.09.017
- VernacularTitle:葛根素对早期2型糖尿病大鼠糖脂代谢及胃动力的影响
- Author:
Weixin LI
;
Rong LIU
;
Zhenzhen PENG
;
Xiang YAN
;
Zhiyuan MA
- Publication Type:Journal Article
- Keywords:
Puerarin;
type 2 diabetes mellitus;
fatty acids nonesterified;
blood glucose;
gastric emptying;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(9):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Puerarin on glucose and lipid metabolism and gastric motility in early period type 2 diabetic (T2DM) rats.Methods Rat model of T2DM was established by high fat-sugar diet fed and low-dose streptozotocin-treated. SD rats were divided randomly into normal control group (NC), normal+Puerarin group (NP), diabetes control group (DC) and diabetes+Puerarin group (DP). NP and DP rats were given Puerarin 400 mg/(kg?d) once per day for 5 weeks, NC and DC rats were given PBS. Half time of gastric emptying and emptying rate were evaluated by SPECT. The serum level of FBG, GSP, FFA, TC, TG and INS were measured by kit.Results Compared with NC group, DC rats had higher FBG, FFA, TC, GSP, TG and emptying rate, but INS and half time of gastric emptying decreased significantly (P<0.05,P<0.01). Compared with DC group, TG, GSP, FFA and emptying rate of DP rats were reduced (P<0.05), but had more half time of gastric emptying (P<0.05). The results of multivariate stepwise regression analysis showed that FBG related to half time of gastric emptying.Conclusion Type 2 diabetic rats have faster gastric motility, higher blood glucose and lipid. Puerarin might improve the disorders of GSP, TG, FFA and gastric emptying in diabetic rats.
