Bioavailability comparison between ligusticum wallichii microemulsion and decoction in rabbits
10.3760/cma.j.issn.1673-4246.2014.09.014
- VernacularTitle:川芎微乳与川芎水煎液在家兔体内的生物利用度对比研究
- Author:
Jun DING
;
Hong DU
;
Xiaoyan LIU
;
Wei SHI
- Publication Type:Journal Article
- Keywords:
Ligusticum wallichii;
Microemulsion;
HPLC;
Bioavailability
- From:
International Journal of Traditional Chinese Medicine
2014;(9):821-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference in bioavailability of ligusticum wallichii microemulsion and decoction by detecting the concentration of Ferulic acid in rabbit plasma. Methods RP-HPLC was used to detect the concentration of Ferulic acid in rabbits plasma at different times, and software 3p87 was used to analyze the pharmacokinetics parameter. Results The pharmacokinetics parameters of ligusticum wallichii microemulsion and decoction were as follows: AUC0-9=2 123.6 μg/(ml?min), Cmax=5.086 μg/ml, Tpeak=56.26 min for microemulsion;Decoction:AUC0-9=878.35 μg/(ml?min), Cmax=2.427μg/ml, Tpeak=128.86 min for decoction, F(%)=241.77. Conclusion Microemulsion of ligusticum wallichii has a higher biological availability and shorter peak time than decoction.
