Safety and histocompatibility of a novel biogradable stent implanted into the coronary artery in a porcine model
10.3969/j.issn.2095-4344.2014.34.004
- VernacularTitle:生物全降解药物支架植入小型猪冠状动脉：安全性及组织相容性
- Author:
Zhao LU
;
Xuejun JIANG
;
Gaoke FENG
;
Xiaoxin ZHENG
;
Jun LI
;
Chaoshi QIN
;
Weiwang GU
;
Qun WANG
;
Qingru XU
;
Yimei HUANG
;
Jiuhao CHEN
- Publication Type:Journal Article
- Keywords:
coronary vessels;
calcium phosphates;
histocompatibility
- From:
Chinese Journal of Tissue Engineering Research
2014;(34):5429-5433
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In order to solve the problems of poly-l-lactic acid (PLLA) stents, such as poor support, acidic metabolites, we researched a novel biogradable stent-PLLA/amorphous calcium plosphate (ACP).
OBJECTIVE: To discuss the safety and histocompatibility of the novel biogradable stent-PLLA/ACP stent implanted in the coronary artery in a porcine model.
METHODS:Sixteen novel biogradable stents were randomly implanted into the coronary arteries, left anterior descending branch, left circumflex artery or right coronary artery of sixteen healthy Tibet miniature pigs. The blood routine and blood biochemistry were measured pre-operation and at 1 month after operation. The coronary blood vessels where the stent was implanted were examined by hematoxylin-eosin staining at 1 and 6 months after operation.
RESULTS AND CONCLUSION: Compared with pre-operation, the post-operation indicators of the blood routine and blood biochemistry were of no significant difference. Coronary angiography revealed coronary artery patency and no thrombosis, the vascular stent segments exhibited clear boundaries with the surrounding tissue, with no tissue adhesion, necrosis, and adherence abnormalities. The results of hematoxylin-eosin staining showed that there was no significant difference in vascular injury integral between 1 month after operation and 6 months after operation. However, 6 months after operation, the scores of the inflammation were lower (P < 0.05), and the scores of the endothelialization were increased (P < 0.05). There was no myocardial infarction and inflammatory cellinfiltration around the stent. These results suggest that the novel biodegradable stent has good safety and histocompatibility.
