Mouse nerve growth factor injection via different ways for treatment of peripheral nerve injury
10.3969/j.issn.2095-4344.2014.33.019
- VernacularTitle:鼠神经生长因子不同给药方式修复周围神经损伤
- Author:
Qingzhen CHEN
;
Mingxiang SHI
;
Shengfei LIU
;
Lanxiang DU
;
Jiangqun LI
- Publication Type:Journal Article
- Keywords:
nerve growth factor;
peripheral nerves;
evoked potentials,motor;
evoked potentials,somatosensory
- From:
Chinese Journal of Tissue Engineering Research
2014;(33):5356-5360
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Mouse nerve growth factor can promote the repair and regeneration of injured nerves, but current experimental research shows that the effects of different treatment methods are stil controversial.
OBJECTIVE:To evaluate the effect of mouse nerve growth factor injection via different ways on the treatment of peripheral nerve injury.
METHODS:Total y 52 patients with peripheral nerve injury were randomly assigned into two groups:experimental group (local injection of mouse nerve growth factor, n=27) and control group (systemic administration of mouse nerve growth factor, n=25). The treatment was performed once a day, and lasted for 4 weeks. Then, the clinical efficacy and recovery of neurological function were compared.
RESULTS AND CONCLUSION:The good and effective rates were 85%(n=23) and 93%(n=25) in the experimental group, while 72%(n=18) and 84%(n=21) in the control group, respectively, which were significantly better in the experimental group than the control group (P<0.05). In the experimental group, 13 cases developed transient pain at injection site, including one case of remission undergoing oral analgesics;in the control group, 12 cases had transient pain at injection site, without any treatment. The results suggest that both local and total body injection of mouse nerve growth factor are safe and effective for treatment of peripheral nerve injury, but local injection is superior to systemic administration.
