Role of Wnt signal pathway in osteoblasts:bone-forming or bone-resorbing?
10.3969/j.issn.2095-4344.2014.33.021
- VernacularTitle:Wnt信号通路在成骨细胞中的作用：成骨还是破骨？
- Author:
Yanling LIU
;
Fangbing LI
;
Xi ZHAO
- Publication Type:Journal Article
- Keywords:
osteoporosis;
WNT proteins;
osteoblasts
- From:
Chinese Journal of Tissue Engineering Research
2014;(33):5366-5371
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Wnt signal pathway is involved in the regulation of bone marrow mesenchymal stem cells differentiating into osteoblasts, promotes osteoblasts proliferation and differentiation, inhibits programmed death of osteoblasts, and indirectly affects the function of osteoclasts.
OBJECTIVE:To summarize the relationship between Wnt/β-catenin signal pathway and bone disease.
METHODS:A computer-based online search was performed to find papers published between January 2000 and January 2014 in CNKI database and Elsevier database. The key words were“Wnt/β-catenin, osteoblasts, bone marrow mesenchymal stem cells, osteoarthritis, chondrocytes”in Chinese. Documents concerning the effects of Wnt/β-catenin signal pathway on osteoblasts and bone disease were included.
RESULTS AND CONCLUSION:Wnt signaling pathway is consisted of Wnt/β-catenin signal pathway (Wnt typical signal pathway), Wnt/Ca2+signal pathway and Wnt/planar cellpolarity signal pathway. Wnt signaling pathway is one of the most important regulatory systems that plays a key role in modulating the differentiation, proliferation and programmed celldeath of osteoblasts, osteoclasts and chondrocytes. The role of Wnt signal pathway in patients with rheumatoid arthritis is mediated by osteoblasts. The inhibitory factor of Wnt signal pathway in osteoblasts is upregulated, which reduces the ratio of osteoprotegerin/receptor activating factor ligand, promotes the osteoclasts differentiation and immaturation. The researches addressing the components and effect of Wnt signal pathway are important for the special treatment of bone diseases and the prevention of osteoporosis or other bone diseases.
