Mechanism of estrogen and estrogen-related compounds in osteoarthritis:joint protection and repair of bone cartilage cells
10.3969/j.issn.2095-4344.2014.33.022
- VernacularTitle:雌激素及相关化合物干预骨关节炎作用机制：关节保护与骨软骨细胞的修复
- Author:
Jian WANG
;
Hairong TAO
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
estrogens;
bone metabolism;
matrix metalloproteinases;
interleukins;
tumor necrosis factor-alpha
- From:
Chinese Journal of Tissue Engineering Research
2014;(33):5372-5376
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The bone metabolism of osteoarthritis is regulated by estrogen with osteoblasts, osteoclasts and cytokines, as wel as a number of regulatory pathways.
OBJECTIVE:To describe the role of estrogen and estrogen-related compounds for joint protection, repair of bone and cartilage cells, and inhibition of synovitis in osteoarthritis.
METHODS:Author researched PubMed, Embase, Elseveir database from 1992 to 2014, with the key words of“osteoarthritis, estrogens, matrix metal oproteinases, interleukins, tumor necrosis factor-alpha”. After the quality of the included studies was evaluation, valid data were extracted and analyzed.
RESULTS AND CONCLUSION:Estrogen can increase the expression of osteoprotegerin and nuclear factor-κB factor ligands in osteoblasts, inhibit bone resorption, prevent the onset and progression of osteoarthritis. Estrogen upregulates anti-osteoclast cytokines, downregulates pro-osteoclast factors, and contribute to regulate bone metabolism of osteoarthritis patients through bone morphogenetic protein and Wnt signaling. Estrogen promotes the adrenal cortex secretion of glucocorticoids and indirectly inhibits the production of matrix metal oproteinases by the hypothalamus-hypophysis-adrenal gland axis. Exogenous estrogen inhibits bone resorption, which may help to delay the development of osteoarthritis. Estrogen and estrogen-related compounds may inhibit the cartilage loss caused by synovitis and inflammatory factors in the late stage of osteoarthritis.
